Basic, we omitted cases diagnosed with blood pressure from the baseline since these people was basically expected to changes their dieting activities shortly after seeing chance
Immediately following draining the bladders, the players sat on the side for more than five full minutes. Its blood pressure level is actually measured having fun with a great calibrated mercury sphygmomanometer by a trained fitness nurse adopting the a standardized process. The participants set the right case in the good cuff airbag, measured at least step one min between recordings. We discussed blood pressure clients with a hateful out of SBP ? 140 mmHg, a hateful away from DBP ? 90 mmHg marriagemindedpeoplemeet desktop, or providing antihypertensive therapy according to the guidance to own stopping and managing blood pressure level inside the China (2010) 23 . All forms of diabetes and myocardial infarction had been defined based on notice-statement out-of analysis of the a doctor publicly hospitals above the county height. The participants must provide the new certification of diabetes otherwise myocardial infarction. Investigators need ensure the latest patient’s prognosis off proof and you may query the questions ‘Has actually a doctor actually considering you the medical diagnosis away from diabetic issues?
Has actually a physician actually ever considering the medical diagnosis off myocardial infarction? Medication explore try discussed in line with the participants’ care about-report, where investigators must query the participants the next concerns: ‘Are you presently delivering anti-blood pressure levels medicines? Did you use the dental drug, injection from insulin, Chinese old-fashioned medication, otherwise home remedies to alleviate diabetes? According to advice with the reduction and you can therapy of bloodstream lipids when you look at the Chinese grownups (2006), players whom met a minumum of one of the after the criteria: (1) TC ? 6. I and noticed other weight-loss covariates, for example complete slimming down times, times, grain, meat, fruit, create, soaked fatty acid, polyunsaturated oily acidic, cereal fiber, Na, K, and you may cholesterol intake, since surrogates to control potential fat loss confounding.
The fresh collective average intake from calcium supplements, magnesium, and phosphorus are computed to reduce within-people variation which means that obtain an educated estimate of one’s enough time-identity intake. Person-numerous years of realize-right up for each participant was in fact calculated while the period involving the date out-of completing of the baseline questionnaire and prevent regarding follow-upwards (the brand new date of one’s history see or the visit out-of coronary arrest diagnosis), any emerged basic. The newest occurrence speed was computed by the breaking up the number of circumstances because of the person-several years of follow-right up. The fresh new multivariate Cox proportional perils activities were used so you’re able to guess this new risk ratios (HR) and you will 95% believe periods (95% CI) of developing stroke considering weight reduction calcium, magnesium, and you may phosphorus consumption with the reduced quartile as site class. Regarding Cox proportional problems designs, this new p having development is done from the modeling the latest average away from the new classes defined by for each quartile because the a continuing changeable.
We first performed statistical interaction tests between dietary intakes of calcium, magnesium, phosphorus, and other baseline characteristics (Table 1). We used the Kolmogorov-Sminov test to test the normality of all variables. We outlined the baseline characteristics of the participants. We used the t-test for the continuous variables with normal distribution to test for differences and trends between groups. The non-parametric test is applied to the continuous variables with non-normal distribution, and the chi-square test is used for the classified variables. Then, we categorize the three-day average intakes of calcium, magnesium, phosphorus into four levels. We constructed three sequential models to estimate the effect of calcium, magnesium, phosphorus intakes on stroke. Model 2 further added baseline sociodemographic and lifestyle factors such as urbanization index, education, household income, smoking status, alcohol intake, physical activity, BMI, hypertension, diabetes, myocardial infarction, and medication use into the multivariable analysis. Model 3 additionally adjusted for dietary factors including energy (kcal/d), whole grain (g/d), red meat (g/d), fruits (g/d), vegetables (g/d), saturated fatty acid (g/d), polyunsaturated fatty acid (g/d), cereal fiber (g/d), Na (mg/d), K (mg/d) and cholesterol (g/d) 24,25,26 . To further analyze which factors would affect the relationship between the exposure and outcome, we conducted stratified analyses by age at baseline (< 60 and ? 60 years), sex (man and woman), smoking (never and ever), drinking (never and ever), BMI (< 24, 24–28 and > 28 kg/m 2 ), hypertension, diabetes, and Myocardial infarction. The likelihood ratio test was used to assess the interactions of cross-product terms. The proportional hazards assumption for dietary calcium, magnesium, phosphorus Intakes, and other covariates was checked by Schoenfeld’s residuals, and no violation was found (P > 0.05). Besides, we performed sensitivity analyses to verify the robustness of the primary results. Second, we repeated the analysis using the non-adjusted person-time from the date of the first visit to the time of the most recent visit of stroke diagnosis or to the end of follow-up, whichever came first. Third, we included dyslipidemia as a sensitivity analysis, which confirmed the robustness of our findings to some degree. Tests for trends across dietary intake categories were conducted by modeling the median value in each quartile as a continuous variable in each model. All statistical analyses were performed with STATA version 14.0. All P-values were two-sided, and P < 0.05 was considered to statistical significance.